Biomarkers
# Receptor name Molecule type Grade of glioma Level in comparison with normal cells or see notes Level in comparison with normal brain cells or see notes (fold) Positive cells (%) Positive samples (%) Precense in membrane Methods Note Reference
1 c-ROS Protein 4 29.0 Immunohistochemistry link
2 c-ROS Protein 3 19.0 Immunohistochemistry link
3 c-ROS Protein 2 23.0 Immunohistochemistry link
4 CD133 mRNA 4 10.0 RT-PCR link
5 CRLR Protein 4 100.0 Immunohistochemistry Note link
6 CRLR Protein 3 100.0 Immunohistochemistry Note link
7 CTR Protein 4 90.0 75.0 Immunohistochemistry link
8 CTR Protein 4 83.0 Immunohistochemistry link
9 CX3CR1 mRNA 4 3 RT-PCR link
10 CX3CR1 Protein 4 3 Immunohistochemistry link
11 CXCR4 mRNA 4 3 2 1 RT-PCR link
12 CXCR4 mRNA 4 10.0 RT-PCR link
13 CXCR4 mRNA 1 2 0.7 RT-PCR link
14 CXCR4 mRNA 4 57.0 Hybridization of cDNA arrays RT-PCR link
15 CXCR4 Protein 4 60.0 Immunohistochemistry link
16 CXCR7 mRNA 4 3 RT-PCR link
17 CXCR7 mRNA 1 2 RT-PCR link
18 CXCR7 mRNA 4 2.0 RT-PCR link
19 CXCR7 mRNA 1 2 2.5 RT-PCR link
20 CXCR7 Protein 4 70.0 Immunohistochemistry link
21 CXCR7 Protein 1 2 0.0 Immunohistochemistry link
22 EGFR mRNA 4 0.33 - 3 RT-PCR Note link
23 EGFR mRNA 4 40.0 RT-PCR link
24 EGFR Protein 4 5-95 100.0 Immunohistochemistry Western blotting link
25 EGFR Protein 4 100.0 Immunohistochemistry link
26 EGFR Protein 3 100.0 Immunohistochemistry link
27 EGFR Protein 4 93.0 Immunohistochemistry link
28 EGFR Protein 3 81.0 Immunohistochemistry link
29 EGFR Protein 2 60.0 Immunohistochemistry link
30 EGFR Protein 1 57.0 Immunohistochemistry link
31 EGFR Protein 4 86.0 Immunohistochemistry link
32 EGFR Protein 3 57.0 Immunohistochemistry link
33 EGFRvIII mRNA RT-PCR Note link
34 EGFRvIII Protein 40.0 Immunohistochemistry Note link
35 EGFRvIII Protein Western blotting Note link
36 EGFRvIII Protein 4 62.0 Immunohistochemistry link
37 EGFRvIII Protein 3 14.0 Immunohistochemistry link
38 EphA2 Protein 4 50-100 91.0 Immunohistochemistry Western blotting Note link
39 EphA2 Protein 3 50-100 54.0 Immunohistochemistry Western blotting Note link
40 EphA2 Protein 2 50-100 38.0 Immunohistochemistry Western blotting Note link
41 EphA2 Protein 0 50-100 0.0 Immunohistochemistry Western blotting Note link
42 EphA2 Protein 4 93.0 Immunohistochemistry Immunofluorescence Western blotting link
43 ERBB3 mRNA 4 RT-PCR link
44 ERBB3 Protein 4 77.0 Immunohistochemistry Western blotting link
45 ERBB3 Protein 4 22.0 Immunohistochemistry link
46 ERBB3 Protein 3 20.0 Immunohistochemistry link
47 ERBB4 mRNA 4 RT-PCR link
48 ERBB4 mRNA 4 0.8 RT-PCR link
49 ERBB4 Protein 4 88.0 Immunohistochemistry Western blotting link
50 ERBB4 Protein 4 66.0 Immunohistochemistry link
51 ERBB4 Protein 3 80.0 Immunohistochemistry link
52 FGFR1 mRNA 4 4.0 RT-PCR link
53 FGFR1 mRNA 4 100.0 Southern blotting link
54 FGFR1 Protein 4 Immunohistochemistry link
55 FGFR1 Protein 4 Immunohistochemistry link
56 FGFR1 Protein 4 Immunohistochemistry link
57 FGFR2 mRNA 4 0.2 RT-PCR link
58 FGFR2 mRNA 4 Southern blotting link
59 FPR1 Protein 4 100.0 Immunohistochemistry link
60 FPR1 Protein 3 77.0 Immunohistochemistry link
61 FPR1 Protein 2 15.0 Immunohistochemistry link
62 GluR1 Protein 4 60.0 14.0 Immunohistichemistry Immunocytochemistry link
63 GluR2 Protein 4 60.0 36.0 Immunohistichemistry Immunocytochemistry link
64 HER2 mRNA 4 0.33 - 3 RT-PCR Note link
65 HER2 Protein 4 85.2 Immunohistochemistry Note link
66 HER2 Protein 3 Immunohistochemistry Note link
67 HER2 Protein 4 3-43 100.0 Immunohistochemistry Western blotting link
68 HER2 Protein 4 77.0 Immunohistochemistry link
69 HER2 Protein 3 100.0 Immunohistochemistry link
70 IL13Rα2 Protein 4 50-100 78.0 Immunohistochemistry Western blotting Note link
71 IL13Rα2 Protein 3 50-100 36.0 Immunohistochemistry Western blotting Note link
72 IL13Rα2 Protein 2 50-100 25.0 Immunohistochemistry Western blotting Note link
73 IL13Rα2 Protein 0 50-100 13.0 Immunohistochemistry Western blotting Note link
74 MELK mRNA 4 100.0 RT-PCR link
75 MELK mRNA 4 250.0 Hybridization of cDNA arrays link
76 MELK mRNA 3 120.0 Hybridization of cDNA arrays link
77 MELK mRNA 2 90.0 Hybridization of cDNA arrays link
78 NgR mRNA 4 0.17 RT-PCR link
79 NgR mRNA 3 0.3 RT-PCR link
80 NgR mRNA 2 0.5 RT-PCR link
81 NgR mRNA 1 0.7 RT-PCR link
82 NgR Protein 4 0.2 Western blotting link
83 NgR Protein 3 0.3 Western blotting link
84 NgR Protein 2 0.5 Western blotting link
85 NgR Protein 1 0.8 Western blotting link
86 NgR Protein 4 0.2 Immunohistichemistry link
87 NgR Protein 3 0.4 Immunohistichemistry link
88 NgR Protein 2 0.7 Immunohistichemistry link
89 NgR Protein 1 0.9 Immunohistichemistry link
90 Notch1 mRNA 4 10.0 RT-PCR link
91 Notch1 mRNA 4 5.2 RT-PCR link
92 Notch1 mRNA 3 3.6 RT-PCR link
93 Notch1 mRNA 2 2.5 RT-PCR link
94 Notch1 mRNA 1 1.3 RT-PCR link
95 Notch1 Protein 4 87.0 Immunohistochemistry Western blotting link
96 Notch1 Protein 3 70.0 Immunohistochemistry Western blotting link
97 Notch1 Protein 2 54.0 Immunohistochemistry Western blotting link
98 Notch1 Protein 1 52.0 Immunohistochemistry Western blotting link
99 Notch1 Protein 4 90.0 Immunohistochemistry link
100 Notch1 Protein 3 70.0 Immunohistochemistry link
101 Notch1 Protein 2 46.0 Immunohistochemistry link
102 Notch1 Protein 1 26.0 Immunohistochemistry link
103 Notch1 Protein 4 100.0 Immunohistochemistry link
104 Notch1 Protein 3 93.0 Immunohistochemistry link
105 Notch1 Protein 2 67.0 Immunohistochemistry link
106 Notch1 Protein 1 60.0 Immunohistochemistry link
107 Notch2 mRNA 4 7.0 RT-PCR link
108 Notch2 Protein 4 0.0 Immunohistochemistry link
109 Notch2 Protein 3 7.0 Immunohistochemistry link
110 Notch2 Protein 2 13.0 Immunohistochemistry link
111 Notch2 Protein 1 20.0 Immunohistochemistry link
112 Notch3 mRNA 4 2.0 RT-PCR link
113 Notch3 Protein 4 100.0 Immunohistochemistry link
114 Notch3 Protein 3 93.0 Immunohistochemistry link
115 Notch3 Protein 2 67.0 Immunohistochemistry link
116 Notch3 Protein 1 53.0 Immunohistochemistry link
117 Notch4 mRNA 4 1.0 RT-PCR link
118 Notch4 Protein 4 100.0 Immunohistochemistry link
119 Notch4 Protein 3 93.0 Immunohistochemistry link
120 Notch4 Protein 2 73.0 Immunohistochemistry link
121 Notch4 Protein 1 47.0 Immunohistochemistry link
122 PDGFRA mRNA 4 10.0 RT-PCR link
123 PDGFRA mRNA 4 90.9 RT-PCR link
124 PDGFRA mRNA 4 9.1 RT-PCR link
125 PDGFRA mRNA 3 96.4 RT-PCR link
126 PDGFRA mRNA 3 3.6 RT-PCR link
127 PDGFRA mRNA 2 100.0 RT-PCR link
128 PDGFRA mRNA 2 0.0 RT-PCR link
129 PDGFRB mRNA 4 2.0 RT-PCR link
130 TfR Protein 4 8.0 Immunohistochemistry Western blotting link
131 TfR Protein 3 3.0 Immunohistochemistry Western blotting link
132 TfR Protein 1 2 2.0 Immunohistochemistry Western blotting link
133 uPAR mRNA 4 15.0 Nothern blotting link
134 uPAR mRNA 3 5.0 Nothern blotting link
135 uPAR mRNA 1 2 1.0 Nothern blotting link
136 uPAR Protein 4 8.0 Radioreceptor assays Immunohistochemistry link
137 uPAR Protein 3 3.0 Radioreceptor assays Immunohistochemistry link
138 uPAR Protein 1 2 1.0 Radioreceptor assays Immunohistochemistry link
139 VEGFR1 mRNA 4 0.8 RT-PCR link
140 VEGFR1 Protein 4 Immunohistochemistry link
141 VEGFR2 mRNA 4 5.0 RT-PCR link
142 VEGFR2 Protein 4 Immunohistochemistry link
143 VEGFR3 mRNA 4 9.0 RT-PCR link
144 VEGFR3 Protein 4 100.0 Immunohistochemistry Note link
# Receptor name Molecule type Object Cell line(s) Grade of glioma Level in comparison with normal brain cells or see notes Level in comparison with normal brain cells or see notes (fold) Positive cells (%) Precense in membrane Methods Note Reference
1 c-ROS mRNA Cell line U87 4 QRT-PCR Note link
2 c-ROS mRNA Cell line SNB19 A172 4 QRT-PCR Note link
3 c-ROS mRNA Cell line U373 U251 SF539 SNB75 SF295 SNB78 4 QRT-PCR Note link
4 c-ROS mRNA Cell line SW1088 SW1783 3 QRT-PCR Note link
5 c-ROS mRNA Cell line U343 T98G SF268 U343 LN229 4 QRT-PCR Note link
6 c-ROS mRNA Cell line HS638 3 QRT-PCR Note link
7 CCR1 Protein Cell line SW1033 SW1783 3 Flow cytometry link
8 CCR1 Protein Cell line PTP/96 IPMS NP750/96 U373 4 Flow cytometry link
9 CCR2 Protein Cell line SW1033 SW1783 3 Flow cytometry link
10 CCR2 Protein Cell line PTP/96 IPMS NP750/96 U373 4 Flow cytometry link
11 CCR3 Protein Cell line SW1033 SW1783 3 Flow cytometry link
12 CCR3 Protein Cell line PTP/96 IPMS NP750/96 U373 4 Flow cytometry link
13 CCR4 Protein Cell line SW1033 SW1783 3 Flow cytometry link
14 CCR4 Protein Cell line PTP/96 IPMS NP750/96 U373 4 Flow cytometry link
15 CCR5 Protein Cell line SW1033 SW1783 3 Flow cytometry link
16 CCR5 Protein Cell line PTP/96 IPMS NP750/96 U373 4 Flow cytometry link
17 CCR6 Protein Cell line SW1033 SW1783 3 Flow cytometry link
18 CCR6 Protein Cell line PTP/96 IPMS NP750/96 U373 4 Flow cytometry link
19 CD133 Protein Cell line NCH421k NCH441 NCH644 NCH636 NCH601 NCH475 NCH453 NCH89 NCH125 NCH149 NCH156 NCH342 NCH354 NCH357 NCH376 NCH417 NCH430 NCH465 U251 U373 4 RT-PCR Immunohistochemistry Note link
20 CXCR1 Protein Cell line SW1033 SW1783 3 Flow cytometry link
21 CXCR1 Protein Cell line PTP/96 IPMS NP750/96 U373 4 Flow cytometry link
22 CXCR2 Protein Cell line SW1033 SW1783 3 Flow cytometry link
23 CXCR2 Protein Cell line PTP/96 IPMS NP750/96 U373 4 Flow cytometry link
24 CXCR3 mRNA Cell line IPTP/96 IPMS NP750/96 4 2.3 RT-PCR Note link
25 CXCR3 Protein Cell line SW1033 SW1783 3 Flow cytometry link
26 CXCR3 Protein Cell line PTP/96 IPMS NP750/96 U373 4 Flow cytometry link
27 CXCR3 Protein Cell line A172 T98G U87 U118 U138 4 5.5 Flow cytometry link
28 CXCR4 mRNA Cell line A739 A761 A764 A767 A772 A777 RT-PCR Note link
29 CXCR4 mRNA Cell line U118 4 RT-PCR Note link
30 CXCR4 mRNA Cell line U343 4 RT-PCR Note link
31 CXCR4 mRNA Cell line A767 0.001 RT-PCR Note link
32 CXCR4 mRNA Cell line A172 U87 U138 U173 4 RT-PCR Note link
33 CXCR4 mRNA Cell line SW1783 3 RT-PCR Note link
34 CXCR4 mRNA Cell line 5GB HTB16 GB1690 4 Different hybridization of Atlas Human cDNA expression arrays RT-PCR link
35 CXCR4 Protein Cell line Flow cytometry Note link
36 CXCR4 Protein Cell line SW1033 SW1783 3 Flow cytometry link
37 CXCR4 Protein Cell line PTP/96 IPMS NP750/96 U373 4 Flow cytometry link
38 CXCR5 Protein Cell line SW1033 SW1783 3 Flow cytometry link
39 CXCR5 Protein Cell line PTP/96 IPMS NP750/96 U373 4 Flow cytometry link
40 CXCR7 mRNA Cell line U118 4 0.1 RT-PCR Note link
41 CXCR7 mRNA Cell line A739 A761 A764 A767 A772 A777 50-100 RT-PCR Note link
42 CXCR7 mRNA Cell line U343 4 50-100 RT-PCR Note link
43 CXCR7 mRNA Cell line A172 U87 U138 U173 4 RT-PCR Note link
44 CXCR7 mRNA Cell line SW1783 3 RT-PCR Note link
45 CXCR7 Protein Cell line U118 U343 A739 A761 A764 A767 A772 A777 Western blotting link
46 CXCR7 Protein Cell line Flow cytometry Note link
47 EGFR mRNA Cell line U105 U118 4 200000.0 RT-PCR Note link
48 EGFR mRNA Cell line U138 SF767 4 100000.0 RT-PCR Note link
49 EGFR mRNA Cell line U251 U343 4 30000.0 RT-PCR Note link
50 EGFRvIII mRNA Cell line U87vIII 4 RT-PCR link
51 EGFRvIII mRNA Cell line U87 4 RT-PCR link
52 EGFRvIII Protein Cell line U87vIII 4 Western blotting link
53 EGFRvIII Protein Cell line U87 4 Western blotting link
54 EphA2 Protein Cell line A172 DBTRG05 G48a U87 U251 4 Immunocytochemistry Immunofluorescence Western blotting link
55 ERBB3 mRNA Cell line U105 U118 U138 SF767 4 RT-PCR Note link
56 ERBB3 mRNA Cell line U251 U343 4 RT-PCR Note link
57 ERBB4 mRNA Cell line U105 U118 U138 SF767 4 RT-PCR Note link
58 ERBB4 mRNA Cell line U251 U343 4 RT-PCR Note link
59 ERRα Protein Cell line A172 U87 U118 U373 4 Western blotting link
60 ERRα Protein Cell line T98G U138 LN229 4 Western blotting link
61 ERRγ Protein Cell line A172 U87 4 Western blotting link
62 ERRγ Protein Cell line A172 U118 U373 U138 LN229 4 Western blotting link
63 FGFR1 mRNA Cell line SNB19 U373 U251 4 RT-PCR link
64 FGFR2 mRNA Cell line U251 4 RT-PCR link
65 FGFR2 mRNA Cell line SNB19 U373 4 RT-PCR link
66 FPR1 mRNA Cell line U87 4 RT-PCR Note link
67 FPR1 mRNA Cell line SHG44 4 RT-PCR Note link
68 FPR1 mRNA Primary culture SHG44 3 RT-PCR Note link
69 FPR1 Protein Cell line U87 Note link
70 GluR1 mRNA Cell line U87 4 RT-PCR link
71 GluR1 mRNA Primary culture VU122 VU028 4 RT-PCR link
72 GluR2 mRNA Cell line U87 4 RT-PCR link
73 GluR2 mRNA Primary culture VU122 VU028 4 RT-PCR link
74 GluR2 Protein Cell line U87 Immunocytochemistry link
75 GluR2 Protein Primary culture VU122 4 Immunocytochemistry link
76 GluR2 Protein Primary culture VU028 4 Immunocytochemistry link
77 HER2 mRNA Cell line U105 U118 U138 SF767 4 10000-30000 RT-PCR Note link
78 HER2 mRNA Cell line U251 U343 4 10000-30000 RT-PCR Note link
79 HER2 Protein Cell line U251 4 Immunohistochemistry Flow cytometry Note link
80 IL13Rα1 Protein Cell line SNB19 SF126 T98G U399 U373 SKMG12 4 link
81 IL13Rα1 Protein Cell line SNB19 SF126 T98G U399 U373 SKMG12 4 link
82 IL4Rα Protein Cell line SNB19 SF126 T98G U399 U373 SKMG12 4 link
83 TfR Protein Cell line U251 U87 4 Immunocytochemistry Western blotting link
84 TfR Protein Cell line SNB19 SF295 U373 U138 U118 U87 T98G Immunobeads detection link
85 uPAR mRNA Cell line SW1783 2 2.8 Northern blot Note link
86 uPAR mRNA Cell line UWR3 4 20.0 Northern blot Note link
87 uPAR mRNA Cell line H4 1 2 Northern blot link
88 VEGFR1 mRNA Cell line U343 4 RT-PCR link
89 VEGFR1 mRNA Cell line U138 4 RT-PCR link
90 VEGFR1 mRNA Cell line A789 A790 RT-PCR link
91 VEGFR1 mRNA Cell line U118 4 RT-PCR link
92 VEGFR1 mRNA Cell line A761 A764 A767 A776 A778 A780 RT-PCR link
93 VEGFR1 Protein Cell line U343 4 Immunohistochemistry link
94 VEGFR2 mRNA Cell line U118 U138 U343 4 RT-PCR link
95 VEGFR2 mRNA Cell line A776 RT-PCR link
96 VEGFR2 mRNA Cell line A761 A764 A767 A778 A780 A789 A790 RT-PCR link
97 VEGFR2 Protein Cell line U343 U118 4 Immunohistochemistry link